Non-invasive Assessment of Intracranial Wall Shear Stress Using High-resolution Magnetic Resonance Imaging in combination with Computational Fluid Dynamics Technique
نویسندگان
چکیده
In vivo studies on association between wall shear stress (WSS) and intracranial plaque are deficient. Based the three-dimensional T1-weighted high-resolution magnetic resonance imaging (3DT1 HR-MRI) data of patients with low-grade stenotic (<50%) atherosclerotic middle cerebral artery (MCA) subjects normal MCA, we built a reconstructed WSS model by computational fluid dynamics (CFD) technique. Three-dimensional registration CFD to HR-MRI was performed projections based resolution thickness images. The relationships at each side vessel location were analyzed. A total 94 MCA plaques from 43 50 MCAs MCAs, lower ventral-inferior than dorsal-superior (proximal segment, p < 0.001; 0.001) inner outer curve ( 0.001). similar low regions observed where developed. ratio in that = 0.002). inner-outer Low associated atherosclerosis formation occurred mainly wall, which anatomically opposite orifices penetrating arteries, curve. Overall, results well consistent theory formation. is promising novel method for assessing an individualized vascular profile once validated further studies.
منابع مشابه
Non-invasive assessment of pulsatile intracranial pressure with phase-contrast magnetic resonance imaging
Invasive monitoring of pulsatile intracranial pressure can accurately predict shunt response in patients with idiopathic normal pressure hydrocephalus, but may potentially cause complications such as bleeding and infection. We tested how a proposed surrogate parameter for pulsatile intracranial pressure, the phase-contrast magnetic resonance imaging derived pulse pressure gradient, compared wit...
متن کاملAssessment of Carotid Flow Using Magnetic Resonance Imaging and Computational Fluid Dynamics
متن کامل
Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes.
BACKGROUND AND PURPOSE Although studies have attempted to differentiate intracranial vascular disease using vessel wall magnetic resonance imaging (VWI), none have incorporated multicontrast imaging. This study uses T1- and T2-weighted VWI to differentiate intracranial vasculopathies. METHODS We retrospectively reviewed patients with clinically defined intracranial vasculopathies causing lumi...
متن کاملDifferential Vascular Pathophysiologic Types of Intracranial Atherosclerotic Stroke: A High-Resolution Wall Magnetic Resonance Imaging Study.
BACKGROUND AND PURPOSE Intracranial atherosclerotic stroke (ICAS) has various stroke mechanisms, including branch occlusive disease (BOD), subcortical infarcts caused by parent arterial disease occluding the perforator's orifice, and non-BOD, infarcts beyond the subcortical area caused by artery-to-artery embolism. To test whether these 2 types of ICAS had different vascular pathophysiologies, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fundamental research
سال: 2022
ISSN: ['2096-9457', '2667-3258']
DOI: https://doi.org/10.1016/j.fmre.2021.09.019